CHC – The Cancer & Hematology Centers

Biliary Tract

Name of this trial: Destiny-BTC What type of cancer is this for? Biliary Tract Cancer Who is this trial for? First line for locally advanced or metastatic HER2 expressing biliary tract cancer What biomarkers are involved? HER2 positive (expressing) What is the National Clinical Trial #? NCT06467357   Brief summary of this trial: Phase 3

Breast

Name of this trial: MK-2870-011 (TroFuse-011)  What type of cancer is this for? Triple-Negative Breast Cancer  Who is this trial for? Patients With Previously Untreated Locally Recurrent Unresectable or Metastatic Triple-Negative Breast Cancer  What biomarkers are involved? Expressing PD-L1 at CPS Less Than 10  What is the National Clinical Trial #? NCT06841354; https://clinicaltrials.gov/study/NCT06841354  Brief summary of this trial: A Phase 3, Randomized, Open-label

Colorectal

Name of this trial: Symbiotic-GI-03   What type of cancer is this for? Metastatic colorectal cancer   Who is this trial for? Patients with treatment-naiive metastatic colorectal cancer   What biomarkers are involved? N/A   What is the National Clinical Trial #? NCT07222800  https://clinicaltrials.gov/study/NCT07222800   Brief summary of this trial: AN INTERVENTIONAL, PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-08634404

Esophageal

NAME: GEMINI GASTRIC What type of cancer is this for? Stomach and where the stomach and esophagus join together Phase: II Who is this trial for: Men and women who have stomach cancer, or cancer where the stomach and esophagus meet, that cannot be removed or has spread to other parts of the body What

Gallbladder

NAME: PanTumor3- Biliary Tree What type of cancer is this for:  Liver, gallbladder, bile ducts Phase: II Who is this trial for: Men and women who have cancer in their biliary tract: liver and/or gallbladder and/or bile ducts that has spread to other parts of the body and cannot be taken out. What biomarkers are

Gastric

Name of this trial: CLARITY-Gastric02 What type of cancer is this for? Advanced/Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma Expressing CLDN 18.2 Who is this trial for? Subjects With Previously Untreated, Locally Advanced or Metastatic Gastric, Gastroesophageal Junction, or Esophageal Adenocarcinoma What biomarkers are involved? Positive expression of Claudin 18.2 What is the National Clinical

Kidney

Name of this trial: Artemide-HCC01 What type of cancer is this for? Advanced Hepatocellular Cancer Who is this trial for? Patients who have advanced kidney cancer that have not had prior treatment in advanced setting. What biomarkers are involved? Central PD-L1 testing, however positivity not dependent on inclusivity What is the National Clinical Trial #?

Leukemia

Name of this trial: BGB-11417-303/CLL-RR1 What type of cancer is this for? Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Who is this trial for? Relapsed and/or Refractory What biomarkers are involved?  CLL Cytogenics (eg, del(17p), del(11q), del(13q), and trisomy 12), complex karyotype, and the mutational status of relevant genes such as IGHV, TP53, and other CLL-related prognosis

Liver

NAME: PanTumor3- Biliary Tree What type of cancer is this for:  Liver, gallbladder, bile ducts Phase: II Who is this trial for: Men and women who have cancer in their biliary tract: liver and/or gallbladder and/or bile ducts that has spread to other parts of the body and cannot be taken out. What biomarkers are