Current Clinical Trials

Name: ZYMEWORKS

What type of cancer is this for? Stomach, Gallbladder, Bile Duct, Colon, Rectal and where the stomach and esophagus meet

Phase: II

Who is this trial for? Men and women with GI Cancers, including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer and Colorectal Cancer

What biomarkers are involved? Must be HER2 positive

What is National Clinical Trial #? NCT03929666

https://classic.clinicaltrials.gov/ct2/show/NCT03929666?term=zymeworks&draw=2&rank=3

Brief summary of trial: This trial is looking to see how safe the drug that is being studied (ZW25) is, and how you feel taking it, when it is given along with other cancer medications.

Need to know: Your cancer must be the kind that cannot be removed by a surgeon. Your cancer can be the kind that comes back after treatment, and it can also have spread to other parts of your body.

Where is this trial available?: The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: PanTumor3- Biliary Tree

What type of cancer is this for:  Liver, gallbladder, bile ducts

Phase: II

Who is this trial for: Men and women who have cancer in their biliary tract: liver and/or gallbladder and/or bile ducts that has spread to other parts of the body and cannot be taken out.

What biomarkers are involved? Your cancer cells must be positive for Trop2

What is National Clinical Trial #? NCT05489211

https://classic.clinicaltrials.gov/ct2/show/NCT05489211?term=D926UC00001&draw=2&rank=1

Brief summary of trial:  This trial is looking to see how well the study drug (Dato-DXd) works on biliary tract cancers that have spread, as well as how safe the drug is.

Need to know: You need to have tried either Gemzar & Carboplatin OR Gemzar & Cisplatin in the past.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: SERENA 6

What type of cancer is this for? BREAST

Phase: III

Who is this trial for? Men and women with Breast Cancer that has spread to other parts of the body.

What biomarkers are involved? You must be hormone receptor (HR) positive, HER2 negative and have a positive ESR1 mutation

What is National Clinical Trial #? NCT04964934

https://classic.clinicaltrials.gov/ct2/show/NCT04964934?term=SERENA+6&draw=2&rank=1

Brief summary of trial: This trial looks to see how well AZD9833 (the drug that is being studied) plus palbociclib or abemaciclib works compared to either anastrozole or letrozole plus palbociclib or abemaciclib.

Need to know: You must have tried either anastrozole or letrozole plus a CDK4/6 inhibitor (Abemaciclib, Palbociclib or Ribociclib)

Where is this trial available?: The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

Name: ZYMEWORKS

What type of cancer is this for? Stomach, Gallbladder, Bile Duct, Colon, Rectal and where the stomach and esophagus meet

Phase: II

Who is this trial for? Men and women with GI Cancers, including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer and Colorectal Cancer

What biomarkers are involved? Must be HER2 positive

What is National Clinical Trial #? NCT03929666

https://classic.clinicaltrials.gov/ct2/show/NCT03929666?term=zymeworks&draw=2&rank=3

Brief summary of trial: This trial is looking to see how safe the drug that is being studied (ZW25) is, and how you feel taking it, when it is given along with other cancer medications.

Need to know: Your cancer must be the kind that cannot be removed by a surgeon. Your cancer can be the kind that comes back after treatment, and it can also have spread to other parts of your body.

Where is this trial available?: The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: CARDIFF

What type of cancer is this for? Colon and rectal

Phase: II

Who is this trial for: Men and women who have colorectal cancer that has spread to other parts of the body, and cannot be taken out.

What biomarkers are involved? : Your cancer cells must show a KRAS or NRAS mutation

What is National Clinical Trial #: NCT05593328

https://classic.clinicaltrials.gov/ct2/show/NCT05593328?term=NCT05593328&draw=2&rank=1

Brief summary of trial: This trial is looking to see how effective two different doses of the new drug that is being studied (onvansertib) are in treating your cancer, when they are given along with chemotherapy.

Need to know: You had to have already received an oxaliplatin/fluoropyrimidine-based therapy to treat your cancer.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: ZYMEWORKS

What type of cancer is this for? Stomach, Gallbladder, Bile Duct, Colon, Rectal and where the stomach and esophagus meet

Phase: II

Who is this trial for? Men and women with GI Cancers, including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer and Colorectal Cancer

What biomarkers are involved? Must be HER2 positive

What is National Clinical Trial #? NCT03929666

https://classic.clinicaltrials.gov/ct2/show/NCT03929666?term=zymeworks&draw=2&rank=3

Brief summary of trial: This trial is looking to see how safe the drug that is being studied (ZW25) is, and how you feel taking it, when it is given along with other cancer medications.

Need to know: Your cancer must be the kind that cannot be removed by a surgeon. Your cancer can be the kind that comes back after treatment, and it can also have spread to other parts of your body.

Where is this trial available?: The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: GEMINI GASTRIC

What type of cancer is this for? Stomach and where the stomach and esophagus join together

Phase: II

Who is this trial for: Men and women who have stomach cancer, or cancer where the stomach and esophagus meet, that cannot be removed or has spread to other parts of the body

What biomarkers are involved? Your tumor CANNOT be positive for HER-2.

What is National Clinical Trial #? NCT05702229

https://classic.clinicaltrials.gov/ct2/show/NCT05702229?term=D7986C00001&draw=2&rank=1

Brief summary of trial: This trial is looking to see how well two new drugs (MEDI5752 and AZD2936) work with chemotherapy plans that already exist.

Need to know: This must be the first treatment you receive since finding out your cancer has spread.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: ZYMEWORKS

What type of cancer is this for? Stomach, Gallbladder, Bile Duct, Colon, Rectal and where the stomach and esophagus meet

Phase: II

Who is this trial for? Men and women with GI Cancers, including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer and Colorectal Cancer

What biomarkers are involved? Must be HER2 positive

What is National Clinical Trial #? NCT03929666

https://classic.clinicaltrials.gov/ct2/show/NCT03929666?term=zymeworks&draw=2&rank=3

Brief summary of trial: This trial is looking to see how safe the drug that is being studied (ZW25) is, and how you feel taking it, when it is given along with other cancer medications.

Need to know: Your cancer must be the kind that cannot be removed by a surgeon. Your cancer can be the kind that comes back after treatment, and it can also have spread to other parts of your body.

Where is this trial available?: The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: PanTumor3- Biliary Tree

What type of cancer is this for:  Liver, gallbladder, bile ducts
Phase: II

Who is this trial for: Men and women who have cancer in their biliary tract: liver and/or gallbladder and/or bile ducts that has spread to other parts of the body and cannot be taken out.

What biomarkers are involved? Your cancer cells must be positive for Trop2

What is National Clinical Trial #? NCT05489211

https://classic.clinicaltrials.gov/ct2/show/NCT05489211?term=D926UC00001&draw=2&rank=1

Brief summary of trial:  This trial is looking to see how well the study drug (Dato-DXd) works on biliary tract cancers that have spread, as well as how safe the drug is.

Need to know: You need to have tried either Gemzar & Carboplatin OR Gemzar & Cisplatin in the past.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: ZYMEWORKS

What type of cancer is this for? Stomach, Gallbladder, Bile Duct, Colon, Rectal and where the stomach and esophagus meet

Phase: II

Who is this trial for? Men and women with GI Cancers, including Gastroesophageal Adenocarcinoma, Biliary Tract Cancer and Colorectal Cancer

What biomarkers are involved? Must be HER2 positive

What is National Clinical Trial #? NCT03929666

https://classic.clinicaltrials.gov/ct2/show/NCT03929666?term=zymeworks&draw=2&rank=3

Brief summary of trial: This trial is looking to see how safe the drug that is being studied (ZW25) is, and how you feel taking it, when it is given along with other cancer medications.

Need to know: Your cancer must be the kind that cannot be removed by a surgeon. Your cancer can be the kind that comes back after treatment, and it can also have spread to other parts of your body.

Where is this trial available?: The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: GEMINI GASTRIC

What type of cancer is this for? Stomach and where the stomach and esophagus join together

Phase: II

Who is this trial for: Men and women who have stomach cancer, or cancer where the stomach and esophagus meet, that cannot be removed or has spread to other parts of the body

What biomarkers are involved? Your tumor CANNOT be positive for HER-2.

What is National Clinical Trial #? NCT05702229

https://classic.clinicaltrials.gov/ct2/show/NCT05702229?term=D7986C00001&draw=2&rank=1

Brief summary of trial: This trial is looking to see how well two new drugs (MEDI5752 and AZD2936) work with chemotherapy plans that already exist.

Need to know: This must be the first treatment you receive since finding out your cancer has spread.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

NAME: MK-022

What type of cancer is this for? Kidney

Phase: III

Who is this trial for? Men and women with kidney cancer who have had a kidney removed.

What cell type is involved? You must have a clear cell type of kidney cancer.

What is National Clinical Trial #? NCT05239728

https://classic.clinicaltrials.gov/ct2/show/NCT05239728?term=NCT05239728&draw=2&rank=1

 Brief summary of trial: This trial compares patients who get the study drug (Belzutifan) and pembrolizumab vs. those who get a harmless drug and pembrolizumab, looking at how long patients stay disease-free with each option.

Need to know: You must have had your kidney removed and/or you had the disease that had spread to other parts of your body removed less than 12 weeks before randomization.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

NAME: PanTumor3- Biliary Tree

What type of cancer is this for:  Liver, gallbladder, bile ducts

Phase: II

Who is this trial for: Men and women who have cancer in their biliary tract: liver and/or gallbladder and/or bile ducts that has spread to other parts of the body and cannot be taken out.

What biomarkers are involved? Your cancer cells must be positive for Trop2

What is National Clinical Trial #? NCT05489211

https://classic.clinicaltrials.gov/ct2/show/NCT05489211?term=D926UC00001&draw=2&rank=1

Brief summary of trial:  This trial is looking to see how well the study drug (Dato-DXd) works on biliary tract cancers that have spread, as well as how safe the drug is.

Need to know: You need to have tried either Gemzar & Carboplatin OR Gemzar & Cisplatin in the past.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

NAME: Carmen-LC03

What type of cancer is this for? Non-small-cell lung cancer

Phase: III

Who is this trial for? Men and women with non-squamous, non-small-cell lung cancer who have had treatment (chemo) before.

What biomarkers are involved?  Your tumors must be CEACAM5 positive.

What is National Clinical Trial#? NCT04154956

https://classic.clinicaltrials.gov/ct2/show/NCT04154956?term=NCT04154956&draw=2&rank=1

Brief summary of trial: This trial is looking at which drug works best to keep your disease from growing for the longest period of time.

Need to know: You must have received either Cisplatin or Carboplatin chemotherapy and an “immune checkpoint inhibitor” in your past treatments.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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Name: GENMAB

What type of cancer is this for? Non-small-cell lung cancer

Phase: II

Who is this trial for? Men and women who have non-small-cell lung cancer that has spread to other parts of their body.

What biomarkers are involved? Your tumor must have PD-L1 expression in greater than 1% of your tumor cells.

What is National Clinical Trial #? NCT05117242

https://classic.clinicaltrials.gov/ct2/show/NCT05117242?term=GCT1046&draw=2&rank=1

Brief summary of trial: This study compares how well their new drug works (shrinks the tumors) by itself vs. giving it with “pembrolizumab”.

Need to know: You need to have had the standard treatment (chemo) and an “immune checkpoint inhibitor” as prior treatment.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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Name: IMFORTE

What type of cancer is this for? Small-cell lung cancer

Phase: III

Who is this trial for? Men and women with extensive stage small cell lung cancer who have had a specific chemo plan before.

What biomarkers are involved? None

What is National Clinical Trial #? NCT05091567

https://classic.clinicaltrials.gov/ct2/show/NCT05091567?term=NCT05091567&draw=2&rank=1

Brief summary of trial: This trial is looking at whether Lurbinectedin works better alone, or if it works better when you add Atezolizumab.

Need to know: You need to have had four cycles of a certain chemotherapy plan: Carboplatin, Etoposide and Atezolizumab

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

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Name: ORCHARD

What type of cancer is this for? Non-small-cell lung cancer

Phase: II

Who is this trial for? Men and women with advanced non-small cell lung cancer

What biomarkers are involved? MET, EGFR C797X, EGFR alterations, ALK rearrangement, RET rearrangement, tSCLC/NEC, BRAF

What is National Clinical Trial #? NCT03944772

https://classic.clinicaltrials.gov/ct2/show/NCT03944772?term=D6186C00001&draw=2&rank=1

Brief summary of trial: This study looks at how well the selected treatment works, by measuring the size of the known disease.

Need to know: You must have tried Osimertinib and had your disease grow while on it. Your tumor tissue will be looked at to see if you have any of the biomarkers listed above. That will determine which treatment you will get.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

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Name: Pacific-9

What kind of cancer is this for? Non-small cell lung cancer

Phase: III

Who is this trial for? Men and women with locally advanced (Stage III) non-small cell lung cancer that cannot be removed by a doctor.

What biomarkers are involved? PD-L1, EGFR and ALK

What is National Clinical Trial #? NCT05221840

https://classic.clinicaltrials.gov/ct2/show/NCT05221840?term=D9078C00001&draw=2&rank=1

Brief summary of trial: This study is looking to prove that durvalumab and oleclumab work better than durvalumab and a placebo (harmless medication) do.

Need to know: You must have had a chemo plan that included either Cisplatin or Carboplatin, along with radiation at the same time you were getting chemotherapy. Your disease cannot have grown any bigger since chemo and radiation finished.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

NAME: ACERTA ESCALADE

What kind of cancer is this for? Diffuse Large B-Cell lymphoma.

Phase: III

Who is this trial for? Men and women who are younger than or equal to 75  years old with lymphoma that has never been treated before. 

What biomarkers are involved? None

What is National Clinical Trial #? NCT04529772

https://classic.clinicaltrials.gov/ct2/show/NCT04529772?term=D8227C00001&draw=2&rank=1

Brief summary of trial: This trial is looking to see if the study drug (acalabrutinib) added to RCHOP (chemo plan) works better than RCHOP and a harmless drug.

Need to know: You must be younger or equal to 75 years old and your cancer cell type must be non-germinal center B-cell lymphoma.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

NAME: IDE196-009

What kind of cancer is this for? Uveal melanoma

Phase: II

Who is this trial for? Men and women with primary uveal melanoma that requires either removal of the eye or radiation therapy.

What biomarkers are involved? None

What is National Clinical Trial #? NCT05907954

https://classic.clinicaltrials.gov/ct2/show/NCT05907954?term=IDE196-009&draw=2&rank=1

Brief summary of trial: This study is looking to see how people feel while they are taking the study drug, as well as how safe it is.

Need to know: The study drug is a pill, and you will have many eye exams during the trial.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: IDE196-002

What kind of cancer is this for? Metastatic Uveal melanoma

Phase: II/III

Who is this trial for? Men and women with uveal melanoma that has spread to other parts of their body.

What biomarkers are involved? None

What is National Clinical Trial #? NCT05987332

https://classic.clinicaltrials.gov/ct2/show/NCT05987332?term=IDE196-002&draw=2&rank=1

Brief summary of trial: This study is looking at how well the study drug (IDE196) plus crizotinib works, as well as how you feel when taking it.

Need to know: Your serotype must be HLA-A*02:01 negative.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: COBRA

What kind of cancer is this for: Multiple Myeloma

Phase: III

Who is this trial for? Men and women who have just found out that they have multiple myeloma

What biomarkers are involved? None

What is National Clinical Trial#? NCT03729804

https://classic.clinicaltrials.gov/ct2/show/NCT03729804?term=COBRA&draw=2&rank=6

Brief summary of trial: This trial is looking at which treatment plan works better at 12 and 24 months after starting.

Need to know: Both transplant and non-transplant candidates are eligible. Transplant candidates must agree at the time of consent to defer transplant to the end of study treatment.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: COBRA

What kind of cancer is this for: Multiple Myeloma

Phase: III

Who is this trial for? Men and women who have just found out that they have multiple myeloma

What biomarkers are involved? None

What is National Clinical Trial#? NCT03729804

https://classic.clinicaltrials.gov/ct2/show/NCT03729804?term=COBRA&draw=2&rank=6

Brief summary of trial: This trial is looking at which treatment plan works better at 12 and 24 months after starting.

Need to know: Both transplant and non-transplant candidates are eligible. Transplant candidates must agree at the time of consent to defer transplant to the end of study treatment.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: PANCAN

What type of cancer is this for? Pancreatic

Phase: II

Who is this trial for: Men and women who have pancreatic cancer that has spread to other parts of the body

What is National Clinical Trial #? NCT04999969

https://classic.clinicaltrials.gov/ct2/show/NCT04999969?term=AZD0171&draw=2&rank=1

Brief summary of trial: This trial is looking to see how you feel when taking the new drug that is being studied (AZD0171), and how safe it is. It will be given in combination with chemotherapy and a drug called durvalumab.

Where is this trial available?: The Cancer & Hematology Centers

For more information, please call 616-975-3065

Name: CAPITELLO-281

What type of cancer is this for? Prostate

Phase: III

Who is this trial for? Men who have hormone sensitive prostate cancer (testosterone can be stopped or blocked to help prevent cancer growth) that has spread to other parts of the body.

What is National Clinical Trial #? : NCT04493853

https://classic.clinicaltrials.gov/ct2/show/NCT04493853?term=capitello+281&draw=2&rank=1

Brief summary of trial: This trial is looking to see how well capivasertib and abiraterone work compared to a harmless medicine and abiraterone.

Nees to know: Your tumor tissue must be PTEN negative. (PTEN stands for Phosphatase and TENsin homolog deleted on chromosome 10)

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: PanTumor 3- PROSTATE

What type of cancer is this for? Prostate

Phase: II

Who is this trial for? Men with advanced prostate cancer that may have spread to other parts of your body.

What biomarkers are involved? None

What is National Clinical Trial #? NCT05489211

https://classic.clinicaltrials.gov/ct2/show/NCT05489211?term=PanTumor+prostate&draw=2&rank=1

Brief summary of trial: This trial is looking to see what drug combination works better to treat your prostate cancer.

Need to know: Your prostate cancer must be “castration-resistant”, which means that your cancer continues to grow even when your testosterone level is very low.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

NAME: EXACT- Registry trial

What kind of cancer is this for? All cancer types

Phase: N/A

Who is this trial for? Men and women who either have a diagnosis of cancer, a clinical suspicion of cancer, a diagnosis of recurrent cancer or a clinical suspicion of recurrent cancer.

What biomarkers are involved? Multiple

What is National Clinical Trial #?

Brief summary of trial: This study is looking at tissue and blood samples from cancer patients, to study the biomarkers they find in the blood or tissue to help and come up with future therapies.

Need to know: There are no medications in this trial, you would need to give a blood or tissue sample for the sponsor to evaluate.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065

 

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NAME: Oracle- Registry trial

What kind of cancer is this for? All types

Phase: N/A

Who is this trial for? The primary study population will include participants with invasive bladder, ureteral, or renal pelvis carcinoma, non-small cell lung cancer, and breast cancer. Exploratory cohorts include participants with cutaneous melanoma, esophageal carcinoma, gastroesophageal junction carcinoma, gastric adenocarcinoma, pancreatic adenocarcinoma, squamous cell carcinoma of the head and neck, epithelial ovarian/Fallopian tube carcinoma, endometrial cancer, renal cell carcinoma (RCC), and rectal adenocarcinoma.

What biomarkers are involved? None

What is National Clinical Trial #? NCT05059444

https://classic.clinicaltrials.gov/ct2/show/NCT05059444?term=oracle&draw=2&rank=1

Brief summary of trial: This study wants to test an assay that they have developed, which could help detect recurrence in people with certain tumors.

Need to know: There are no medications on this trial, just blood draws and tissue samples are needed.

Where is this trial available? The Cancer & Hematology Centers

For more information, please call 616-975-3065