CHC – The Cancer & Hematology Centers

Lung

Name of this trial: DeLLphi-315 What type of cancer is this for? ES-SCLC (extensive-stage, small cell lung cancer) Who is this trial for?  Patients who have progressed after initial treatment of chemotherapy with or without anti-PD (L)1 therapy. What biomarkers are involved? N/A What is the National Clinical Trial #? NCT07778316   https://clinicaltrials.gov/study/NCT07778316?term=NCT07778316&viewType=Card&rank=1 Brief summary of this trial: Phase 3 randomized trial of subcutaneous

Lymphoma

Name of this trial: BGB-11417-303/CLL-RR1 What type of cancer is this for? Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Who is this trial for? Relapsed and/or Refractory What biomarkers are involved?  CLL Cytogenics (eg, del(17p), del(11q), del(13q), and trisomy 12), complex karyotype, and the mutational status of relevant genes such as IGHV, TP53, and other CLL-related prognosis

Melanoma

Name of this trial: OptimUM-10 What type of cancer is this for? Uveal Melanoma  Who is this trial for? Subjects with Primary Non-metastatic Uveal Melanoma What biomarkers are involved? Monosomy 3  What is the National Clinical Trial #? NCT07015190; https://clinicaltrials.gov/study/NCT07015190 Brief summary of this trial: A Randomized, Phase 3, Open-label Study of Neoadjuvant Darovasertib in

Multiple Myeloma

Name of this trial: Majestic-7 What type of cancer is this for? Multiple Myeloma Who is this trial for? This trial is for patients with newly diagnosed multiple myeloma who are either ineligible or not intended for stem cell transplant as initial therapy. What biomarkers are involved? n/a What is the National Clinical Trial #? NCT05552222   Brief summary of

Pancreas

Name of this trial: DAWN-303 What type of cancer is this for? Metastatic pancreatic cancer Who is this trial for? Patients who have not had any treatment for metastatic pancreatic disease. What biomarkers are involved? KRAS G12D What is the National Clinical Trial #?  NCT07522073  Brief summary of this trial: Randomized, double-blinded, Ph. 3 trial of chemotherapy with or without INCB161734 in previously

Prostate

Name of this trial: Himalayas-1 What type of cancer is this for? Metastatic Castration Resistant Prostate Cancer Who is this trial for?  Patients who have progressed after being treated with Abiraterone Acetate What biomarkers are involved? N/A What is the National Clinical Trial #? NCT07723248  Brief summary of this trial:  Phase 3, randomized trial of investigational drug Rinzimetostat in combination with Darolutamide,

Registry Trial

NAME: EXACT- Registry trial What kind of cancer is this for? All cancer types Phase: N/A Who is this trial for? Men and women who either have a diagnosis of cancer, a clinical suspicion of cancer, a diagnosis of recurrent cancer or a clinical suspicion of recurrent cancer. What biomarkers are involved? Multiple What is

Urothelial

Name of this trial: TROPION-Urothelial03 What type of cancer is this for? Urothelial Carcinoma Who is this trial for? Subjects With Locally Advanced or Metastatic Urothelial Carcinoma (la/mUC) What biomarkers are involved? TROP2 Protein Expression What is the National Clinical Trial #? NCT07129993; https://clinicaltrials.gov/study/NCT07129993 Brief summary of this trial: A Randomized, Open-Label, Phase 2/3 Study